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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrpprctm1.1Lrsn
targeted mutation 1.1, Nils-Goran Larsson
MGI:5438912
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrpprctm1.1Lrsn/Lrpprctm1.1Lrsn
Tg(Ckmm-cre)5Khn/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:5438914


Genotype
MGI:5438914
cn1
Allelic
Composition		 Lrpprctm1.1Lrsn/Lrpprctm1.1Lrsn
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrpprctm1.1Lrsn mutation (0 available); any Lrpprc mutation (60 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:187800 )
• mice die before 16 weeks of age

cellular
increased mitochondrial DNA content ( J:187800 )
• increased mitochondrial DNA content
increased mitochondrial size ( J:187800 )
• increased mitochondrial mass associated with a severe cytochrome c oxidase deficiency
abnormal mitochondrial physiology ( J:187800 )
• severe cytochrome c oxidase deficiency
• aberrant polyadenyation of mitochondrial mRNA and impaired mRNA stability

cardiovascular system

growth/size/body
enlarged heart ( J:187800 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory