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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dag1tm1.1Swin
targeted mutation 1.1, Steve J Winder
MGI:5438989
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dag1tm1.1Swin/Dag1tm1.1Swin involves: 129S4/SvJae * C57BL/6 MGI:5438995
cx2
 		Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Dmdmdx 		involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn MGI:5438997
cx3
 		Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Y 		involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn MGI:5438998


Genotype
MGI:5438995
hm1
Allelic
Composition		 Dag1tm1.1Swin/Dag1tm1.1Swin
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm1.1Swin mutation (0 available); any Dag1 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:187750 )
• appeared normal and healthy, are born at expected Mendelian ratios and remain so up to 8 months of age




Genotype
MGI:5438997
cx2
Allelic
Composition		 Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Dmdmdx
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm1.1Swin mutation (0 available); any Dag1 mutation (109 available)
Dmdmdx mutation (31 available); any Dmd mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating creatine kinase level ( J:187750 )
• less so than in Dmdmdx homozygotes or hemizygotes
increased susceptibility to injury ( J:187750 )
• muscles exhibit partial protection against contraction-induced injury compared with Dmdmdx homozygotes or hemizygotes

muscle
centrally nucleated skeletal muscle fibers ( J:187750 )
• less so than in Dmdmdx homozygotes or hemizygotes




Genotype
MGI:5438998
cx3
Allelic
Composition		 Dag1tm1.1Swin/Dag1tm1.1Swin
Dmdmdx/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm1.1Swin mutation (0 available); any Dag1 mutation (109 available)
Dmdmdx mutation (31 available); any Dmd mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating creatine kinase level ( J:187750 )
• less so than in Dmdmdx homozygotes or hemizygotes
increased susceptibility to injury ( J:187750 )
• muscles exhibit partial protection against contraction-induced injury compared with Dmdmdx homozygotes or hemizygotes

muscle
centrally nucleated skeletal muscle fibers ( J:187750 )
• less so than in Dmdmdx homozygotes or hemizygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory