All Phenotypes Defb41<tm1(icre)Psip> MGI Mouse

oligozoospermia ( J:187838 )

• sperm number is reduced in mutant epididymides; at 6 months, number of tubular cross sections without sperm is increased due to obstruction of efferent ducts; however, number of sperm with angulated tails is not increased at 2 months compared to controls

abnormal seminiferous tubule epithelium morphology ( J:187838 )

• disruption of epithelium resulting from fluid back-pressure is noted in 6-month old mice

abnormal efferent ductules of testis morphology ( J:187838 )

• efferent ducts are enlarged at 2 months

dilated efferent ductule of testis ( J:187838 )

abnormal epididymis morphology ( J:187838 )

• mutant males have a thicker smooth muscle layer than controls at 2 months, showing 3 muscle cell layers surrounding epididymal duct compared to one in controls

abnormal epididymis epithelium morphology ( J:187838 )

• initial segment (IS) of epididymis is much smaller than in controls and cannot be distinguished from the caput epididymis (CAP) whereas in controls the IS is readily discerned due to endogenous beta-gal activity

• epithelial cell layer is disorganized in mutants at 2 months with greater disturbance observed in 6-month old males

• numbers of apoptotic cells are higher in the IS and CAP of mutants relative to controls

• height of epithelium in initial segment of mutants is reduced below that of control animals; epithelial cell height in IS of mutants is significantly lower than in controls

• epithelial cells of IS in 45 day-old animals show regression to an undifferentiated state similar to that observed at 14 days

small epididymis ( J:187838 )

• despite increased cell proliferation, epididymides of mutants are significantly smaller than control (by weight at 2 months, but at 6 months there is no significant difference in epididymides weights)

male infertility ( J:187838 )

• 2-3 month-old males fail to produce offspring when mated to wild-type females, even though sperm is detected in the cauda epididymides

increased epididymal epithelium cell proliferation ( J:187838 )

• increased cell proliferation is observed in the proximal epididymides of 2 month-old mice based on Ki-67 staining (about 2-fold higher in the initial segment (IS) and 6-fold higher in the caput region (CAP) in mutants vs. control)

abnormal seminiferous tubule epithelium morphology ( J:187838 )

• disruption of epithelium resulting from fluid back-pressure is noted in 6-month old mice

oligozoospermia ( J:187838 )

• sperm number is reduced in mutant epididymides; at 6 months, number of tubular cross sections without sperm is increased due to obstruction of efferent ducts; however, number of sperm with angulated tails is not increased at 2 months compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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