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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfattm2.1Sawa
targeted mutation 2.1, Senji Shirasawa
MGI:5439020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zfattm2.1Sawa/Zfattm2.1Sawa
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6JJcl * C57BL/6NCrSlc * DBA/2 MGI:5439028


Genotype
MGI:5439028
cn1
Allelic
Composition		 Zfattm2.1Sawa/Zfattm2.1Sawa
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JJcl * C57BL/6NCrSlc * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Zfattm2.1Sawa mutation (0 available); any Zfat mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:187164 )
N
• the number of B cells is normal
increased T cell apoptosis ( J:187164 )
• in TCR-stimulated T cells
decreased T cell proliferation ( J:187164 )
• in TCR-stimulated T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:187164 )
• impaired maturation of CD8 single positive thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:187164 )
• in the lymph node, spleen and peripheral blood
• 7.4-fold in the spleen
decreased interleukin-2 secretion ( J:187164 )
• in TCR-stimulated T cells

cellular
increased T cell apoptosis ( J:187164 )
• in TCR-stimulated T cells
decreased T cell proliferation ( J:187164 )
• in TCR-stimulated T cells

hematopoietic system
increased T cell apoptosis ( J:187164 )
• in TCR-stimulated T cells
decreased T cell proliferation ( J:187164 )
• in TCR-stimulated T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:187164 )
• impaired maturation of CD8 single positive thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:187164 )
• in the lymph node, spleen and peripheral blood
• 7.4-fold in the spleen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory