Phenotypes associated with this allele

• Allele Symbol: Dhx58^tm1Itl
• Allele Name: targeted mutation 1, inGenious Targeting Laboratory
• Allele ID: MGI:5439127
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx58^tm1Itl/Dhx58^tm1Itl	C57BL/6-Dhx58^tm1Itl	MGI:5439145
cx2	Adar^em1Stsn/Adar^tm1Olds Dhx58^tm1Itl/Dhx58^tm1Itl	involves: 129S/SvEv * C57BL/6J * C57BL/6NTac	MGI:7281847

Genotype
MGI:5439145

hm1

• Allelic Composition: Dhx58^tm1Itl/Dhx58^tm1Itl
• Genetic Background: C57BL/6-Dhx58^tm1Itl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:187386 )

• in mice infected with West Nile Virus

immune system

increased T cell apoptosis ( J:187386 )

• of CD8+ T cells in mice infected with West Nile Virus 10 days post-infection

• of CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

• regulation of cell survival is cell-intrinsic

decreased interferon-beta secretion ( J:187386 )

• macrophages and dendritic cells infected with West Nile Virus exhibit reduced IFN-beta production compared with wild-type cells

decreased interferon-gamma secretion ( J:187386 )

• in re-stimulated splenocytes and CD8+ T cells from mice infected with West Nile Virus

decreased tumor necrosis factor secretion ( J:187386 )

• in re-stimulated splenocytes and CD8+ T cells from mice infected with West Nile Virus

increased susceptibility to Flaviviridae infection ( J:187386 )

• macrophages and dendritic cells infected with West Nile Virus exhibit reduced IFN-beta production and increased virus replication (24 hr post-infection) compared with wild-type cells

• mice infected with West Nile Virus exhibit extensive neuron damage, increased viral load and reduced CD8+ T cells numbers in the brain and spleen increased apoptosis (10 days post-infection) compared with wild-type mice

• mice infected with lymphocytic choriomeningitis virus exhibit increased CD8+ T cell apoptosis compared with wild-type mice

• however, mice infected with West Nile Virus exhibit normal innate immune response and viral replication in neurons

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:187386 )

• in mice infected with West Nile Virus

cellular

increased T cell apoptosis ( J:187386 )

• of CD8+ T cells in mice infected with West Nile Virus 10 days post-infection

• of CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

• regulation of cell survival is cell-intrinsic

hematopoietic system

increased T cell apoptosis ( J:187386 )

• of CD8+ T cells in mice infected with West Nile Virus 10 days post-infection

• of CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

• regulation of cell survival is cell-intrinsic

Genotype
MGI:7281847

cx2

• Allelic Composition: Adar^em1Stsn/Adar^tm1Olds; Dhx58^tm1Itl/Dhx58^tm1Itl
• Genetic Background: involves: 129S/SvEv * C57BL/6J * C57BL/6NTac

growth/size/body

growth/size/body region phenotype ( J:308678 )

N • normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N • normal expression of interferon-stimulated genes in cerebellum, kidney and liver

N • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N • normal survival