Phenotypes associated with this allele

• Allele Symbol: Gpr37l1^tm1.2Gtva
• Allele Name: targeted mutation 1.2, Glauco Tocchini-Valentini
• Allele ID: MGI:5439169
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr37l1^tm1.2Gtva/Gpr37l1^tm1.2Gtva	involves: 129S/SvEv * BALB/c * C57BL/6J	MGI:5512669
cx2	Gpr37l1^tm1.2Gtva/Gpr37l1^tm1.2Gtva Ptch1^tm1Zim/Ptch1^+	STOCK Gpr37l1^tm1.2Gtva Ptch1^tm1Zim/Cnrm	MGI:6429905

Genotype
MGI:5512669

hm1

• Allelic Composition: Gpr37l1^tm1.2Gtva/Gpr37l1^tm1.2Gtva
• Genetic Background: involves: 129S/SvEv * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:201190 )

• increased in the external granule cell layer at P3

• decreased in the external granule cell layer at P7

• however, neuron proliferation is un changed at P5

abnormal cerebellum external granule cell layer morphology ( J:201190 )

• altered differentiation

thin external granule cell layer ( J:201190 )

• at P10

abnormal cerebellar layer morphology ( J:201190 )

• decreased a P10 and less so at P15

abnormal Bergmann glial cell differentiation ( J:201190 )

• precocious maturation and expanded reticular domain at P10 and P15

abnormal Purkinje cell differentiation ( J:201190 )

• precocious maturation with alterations in the cell body alignment and dendritic arborization at P10 and P15

• however, Purkinje arborization is normal at P20

abnormal cerebellar molecular layer ( J:201190 )

• increased thickness at P10

behavior/neurological

abnormal motor learning ( J:201190 )

• improved

enhanced coordination ( J:201190 )

♂ • male mice exhibit increased improved performance on a rotarod with longer latency to fall at 6 and 12 months compared with wild-type mice

abnormal locomotor activation ( J:201190 )

♂ • male mice exhibit stronger negative geotaxis and higher climbing reflex at P10 compared with wild-type mice

vision/eye

early eyelid opening ( J:201190 )

♂ • in male mice

cellular

abnormal Bergmann glial cell differentiation ( J:201190 )

• precocious maturation and expanded reticular domain at P10 and P15

abnormal Purkinje cell differentiation ( J:201190 )

• precocious maturation with alterations in the cell body alignment and dendritic arborization at P10 and P15

• however, Purkinje arborization is normal at P20

abnormal neuronal precursor proliferation ( J:201190 )

• increased in the external granule cell layer at P3

• decreased in the external granule cell layer at P7

• however, neuron proliferation is un changed at P5

Genotype
MGI:6429905

cx2

• Allelic Composition: Gpr37l1^tm1.2Gtva/Gpr37l1^tm1.2Gtva; Ptch1^tm1Zim/Ptch1⁺
• Genetic Background: STOCK Gpr37l1^tm1.2Gtva Ptch1^tm1Zim/Cnrm

neoplasm

increased tumor incidence ( J:272049 )

• increased noninvasive tumors compared to in Ptch1^tm1Zim heterozygotes

increased medulloblastoma incidence ( J:272049 )

• mice develop medulloblastomas at a reduced incidence and delayed onset with reduced hydrocephalus compared with Ptch1^tm1Zim heterozygotes

increased tumor latency ( J:272049 )

• compared to in Ptch1^tm1Zim heterozygotes

nervous system

decreased cerebellar granule cell precursor proliferation ( J:272049 )

• compared to in Ptch1^tm1Zim heterozygotes

increased medulloblastoma incidence ( J:272049 )

• mice develop medulloblastomas at a reduced incidence and delayed onset with reduced hydrocephalus compared with Ptch1^tm1Zim heterozygotes

hydrocephaly ( J:272049 )

• reduced compared to in Ptch1^tm1Zim heterozygotes

cellular

decreased cerebellar granule cell precursor proliferation ( J:272049 )

• compared to in Ptch1^tm1Zim heterozygotes