Analysis Tools
behavior/neurological
growth/size/body
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• mice show slower rate of weight gain from 2 to 6 weeks of age
• however, body weight catches up to that of controls by 2 months of age
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nervous system
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• mice develop an early-onset of leukoencephalopathy
• however, mice do not exhibit macrocephaly
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• an empty space is seen in the corpus callosum first at P7 and persists throughout later ages
• mice fed doxcycyline-containing chow from the time of conception to P28 then a normal chow for an additional 10 days resulting in gene overexpression from P28 to P38 show expanded electron-lucent areas surrounding the vasculature in the corpus collosum, however, swollen oligodendrocytes or myelin-associated vacuoles are not observed
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• numerous vacuole-like structures are present in the corpus callosum, globus pallidus, internal capsule, fimbria of the hippocampus, and cerebellar peduncles of the white matter
• the lesioned area containing vacuoles shrinks with age after P28
• vacuoles are not seen in the gray matter
• less than 5% of axons are associated with vacuoles; myelin-associated vacuoles are mostly either intra-myelin vacuoles that are entirely surrounded by a split myelin sheath or periaxonal vacuoles which are surrounded by both electron-dense myelin and an inner loop (these vacuoles separate an axon from its myelin sheath)
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• vacuolating lesions in the white matter contain astrocytes with swollen endfeed and mostly normal myelinated axons
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astrocytosis
(
J:237219
)
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• astrocytic activation is seen in both the gray and white matter
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• vacuolating lesions in the matter contain a small percentage of axons with split myelin sheaths
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reproductive system
| N |
• mice exhibit normal fertility
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