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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spaca1tm1.1Osb
targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI:5439282
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spaca1tm1.1Osb/Spaca1tm1.1Osb involves: 129S2/SvPas * C57BL * C57BL/6N * DBA MGI:5439283
cx2
 		Spaca1tm1.1Osb/Spaca1tm1.1Osb
Tg(Acr-EGFP)1Osb/0 		involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA MGI:5439284


Genotype
MGI:5439283
hm1
Allelic
Composition		 Spaca1tm1.1Osb/Spaca1tm1.1Osb
Genetic
Background		 involves: 129S2/SvPas * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca1tm1.1Osb mutation (1 available); any Spaca1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:187685 )
• abnormalities become more apparent as the spermatozoa pass through the epididymis
abnormal sperm flagellum morphology ( J:187685 )
• ectopic localization in mature spermatozoa
coiled sperm flagellum ( J:187685 )
• spermatozoa from the cauda epididymidis show a tail coiled around the head
abnormal sperm head morphology ( J:187685 )
• mature spermatozoa have disorganized mitochondria trapped inside large cytoplasmic droplets and misshapen nuclei
abnormal acrosome morphology ( J:187685 )
• hypoplasia of the intermediate filament bundles in round spermatids
globozoospermia ( J:187685 )
• all testicular spermatozoa show a round-headed morphology
asthenozoospermia ( J:187685 )
• impaired spematozoa swimming ability
male infertility ( J:187685 )
• males, but not females, are sterile
• when fertilization is accomplished by intracytoplasmic sperm injection healthy pups can be produced

cellular
teratozoospermia ( J:187685 )
• abnormalities become more apparent as the spermatozoa pass through the epididymis
abnormal sperm flagellum morphology ( J:187685 )
• ectopic localization in mature spermatozoa
coiled sperm flagellum ( J:187685 )
• spermatozoa from the cauda epididymidis show a tail coiled around the head
abnormal sperm head morphology ( J:187685 )
• mature spermatozoa have disorganized mitochondria trapped inside large cytoplasmic droplets and misshapen nuclei
abnormal acrosome morphology ( J:187685 )
• hypoplasia of the intermediate filament bundles in round spermatids
globozoospermia ( J:187685 )
• all testicular spermatozoa show a round-headed morphology
asthenozoospermia ( J:187685 )
• impaired spematozoa swimming ability




Genotype
MGI:5439284
cx2
Allelic
Composition		 Spaca1tm1.1Osb/Spaca1tm1.1Osb
Tg(Acr-EGFP)1Osb/0
Genetic
Background		 involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca1tm1.1Osb mutation (1 available); any Spaca1 mutation (16 available)
Tg(Acr-EGFP)1Osb mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:187685 )
• abnormalities in acrosome formation are detected in spermatids at around step 6
abnormal acrosome morphology ( J:187685 )
• all round-headed testicular and cauda epididymal spermatozoa have an acrosome of negligible size
• a few spermatozoa have small aberrantly shaped acrosomes
abnormal spermatid morphology ( J:187685 )
• as around step 6 nuclei are smaller and accumulation of GFP in the acrosomal granule is not apparent

cellular
abnormal acrosome morphology ( J:187685 )
• all round-headed testicular and cauda epididymal spermatozoa have an acrosome of negligible size
• a few spermatozoa have small aberrantly shaped acrosomes
abnormal spermatid morphology ( J:187685 )
• as around step 6 nuclei are smaller and accumulation of GFP in the acrosomal granule is not apparent




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory