Phenotypes associated with this allele

• Allele Symbol: Evc2^tm1.1Vlrp
• Allele Name: targeted mutation 1.1, Victor L Ruiz-Perez
• Allele ID: MGI:5439465
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp	involves: 129 * C57BL/6J	MGI:5441350
cx2	Evc^tm1Jago/Evc^tm1Jago Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp	involves: 129 * 129S7/SvEvBrd * C57BL/6J	MGI:5441352

Genotype
MGI:5441350

hm1

• Allelic Composition: Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:188176 )

skeleton

impaired osteoblast differentiation ( J:188176 )

• at the leading edge of the bone collar

abnormal basicranium morphology ( J:188176 )

• in the frontal region

short radius ( J:188176 )

short femur ( J:188176 )

short tibia ( J:188176 )

abnormal long bone epiphyseal plate morphology ( J:188176 )

• most mice exhibit an ectopic protrusion of cartilage in the boundary between proliferating and hypertrophic chondrocytes in the proximal growth plate of the radius

abnormal long bone epiphyseal plate proliferative zone ( J:188176 )

• reduced

decreased width of hypertrophic chondrocyte zone ( J:188176 )

short ribs ( J:188176 )

abnormal chondrocyte physiology ( J:188176 )

• decreased proliferation in the resting zone of the growth plate

• delayed hypertrophy of chondrocytes adjacent to the perichondrium

cellular

impaired osteoblast differentiation ( J:188176 )

• at the leading edge of the bone collar

craniofacial

abnormal basicranium morphology ( J:188176 )

• in the frontal region

limbs/digits/tail

short radius ( J:188176 )

short femur ( J:188176 )

short tibia ( J:188176 )

short limbs ( J:188176 )

• progressive proximodistal shortening

Genotype
MGI:5441352

cx2

• Allelic Composition: Evc^tm1Jago/Evc^tm1Jago; Evc2^tm1.1Vlrp/Evc2^tm1.1Vlrp
• Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:188176 )

skeleton

impaired osteoblast differentiation ( J:188176 )

• in the perichondrium

basisphenoid bone foramen ( J:188176 )

abnormal presphenoid synchondrosis ( J:188176 )

• defects in the intrasphenoidal synchondrosis

abnormal long bone epiphyseal plate morphology ( J:188176 )

• most mice exhibit an ectopic protrusion of cartilage in the boundary between proliferating and hypertrophic chondrocytes in the proximal growth plate of the radius

abnormal long bone epiphyseal plate proliferative zone ( J:188176 )

• reduced

short ribs ( J:188176 )

abnormal chondrocyte physiology ( J:188176 )

• decreased proliferation in the growth plate

cellular

impaired osteoblast differentiation ( J:188176 )

• in the perichondrium

craniofacial

basisphenoid bone foramen ( J:188176 )

abnormal presphenoid synchondrosis ( J:188176 )

• defects in the intrasphenoidal synchondrosis

limbs/digits/tail

short limbs ( J:188176 )