Phenotypes associated with this allele

• Allele Symbol: Magi2^tm1.1Knis
• Allele Name: targeted mutation 1.1, Katsuhiko Nishimori
• Allele ID: MGI:5439615
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Magi2^tm1.1Knis/Magi2^tm1.1Knis	Not Specified	MGI:5660913

Genotype
MGI:5660913

hm1

• Allelic Composition: Magi2^tm1.1Knis/Magi2^tm1.1Knis
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:216062 )

• homozygous mutant pups die within 48 hours after birth; no homozygotes survive to weaning age

• however, gross appearance as well as body and organ weights remain normal

homeostasis/metabolism

increased circulating creatinine level ( J:216062 )

• neonates exhibit a 4-fold increase in plasma creatinine levels relative to wild-type controls

renal/urinary system

abnormal podocyte foot process morphology ( J:216062 )

• neonates exhibit abnormal morphology of podocyte foot processes; the distance between foot processes is dramatically reduced

• foot processes are shortened, and the interdigitating network appears disorganized

fused podocyte foot processes ( J:216062 )

• fusion of the podocyte foot processes results in loss of normal slit diaphragm structure

abnormal podocyte slit diaphragm morphology ( J:216062 )

• no clear slit diaphragms are observed, due to fusion and/or adhesion of the foot processes

anuria ( J:216062 )

• neonates display a lack of urine in the bladder, indicating severe impairment of renal function