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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbn1tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5439622
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:5439643
cn2
 		Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CD-1 MGI:5439642
cn3
 		Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * SJL/J MGI:5439641


Genotype
MGI:5439643
cn1
Allelic
Composition		 Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.1Itl mutation (1 available); any Fbn1 mutation (173 available)
Fbn1tm3Rmz mutation (1 available); any Fbn1 mutation (173 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

respiratory system

homeostasis/metabolism




Genotype
MGI:5439642
cn2
Allelic
Composition		 Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.1Itl mutation (1 available); any Fbn1 mutation (173 available)
Fbn1tm3Rmz mutation (1 available); any Fbn1 mutation (173 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal trabecular bone morphology ( J:187484 )
• increased trabecular space
abnormal bone trabecula morphology ( J:187484 )
• worse trabeculae morphology compared with Fbn1tm2Rmz homozygotes




Genotype
MGI:5439641
cn3
Allelic
Composition		 Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.1Itl mutation (1 available); any Fbn1 mutation (173 available)
Fbn1tm3Rmz mutation (1 available); any Fbn1 mutation (173 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal trabecular bone morphology ( J:187484 )
• increased trabecular space
abnormal bone trabecula morphology ( J:187484 )
• worse trabeculae morphology compared with Fbn1tm2Rmz homozygotes

hematopoietic system
abnormal bone marrow cell morphology/development ( J:187484 )
• bone marrow stromal cells exhibit more colony forming unit fibroblast than wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory