About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psen1tm1.1Ruvi
targeted mutation 1.1, Ruben Vidal
MGI:5439663
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psen1tm1.1Ruvi/Psen1tm1.1Ruvi C57BL/6J-Psen1tm1.1Ruvi MGI:5439824
cx2
 		Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Tg(APP)8.9Btla/0 		involves: 129S2/SvPas * C57BL/6J MGI:5439825


Genotype
MGI:5439824
hm1
Allelic
Composition		 Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Genetic
Background		 C57BL/6J-Psen1tm1.1Ruvi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation (0 available); any Psen1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:187475 )
N
• male fertility is normal
abnormal ovary morphology ( J:187475 )
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements

homeostasis/metabolism

endocrine/exocrine glands
abnormal ovary morphology ( J:187475 )
• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements




Genotype
MGI:5439825
cx2
Allelic
Composition		 Psen1tm1.1Ruvi/Psen1tm1.1Ruvi
Tg(APP)8.9Btla/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation (0 available); any Psen1 mutation (48 available)
Tg(APP)8.9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:187475 )
• keratan sulfate-positive-activated microglia
amyloid beta deposits ( J:187475 )
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice
astrocytosis ( J:187475 )
• in the cerebral cortex with amyloid deposition
neurodegeneration ( J:187475 )
• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles

immune system
microgliosis ( J:187475 )
• keratan sulfate-positive-activated microglia

hematopoietic system
microgliosis ( J:187475 )
• keratan sulfate-positive-activated microglia

homeostasis/metabolism
amyloid beta deposits ( J:187475 )
• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory