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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlrc3tm1Bhk
targeted mutation 1, Beverly H Koller
MGI:5439971
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nlrc3tm1Bhk/Nlrc3tm1Bhk B6.129S6-Nlrc3tm1Bhk MGI:5439978


Genotype
MGI:5439978
hm1
Allelic
Composition
Nlrc3tm1Bhk/Nlrc3tm1Bhk
Genetic
Background
B6.129S6-Nlrc3tm1Bhk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc3tm1Bhk mutation (0 available); any Nlrc3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slightly greater frequency of peritoneal monocytes in LPS-treated mice
• from macrophages in response to TLR agonists that activate signaling via the Myd88-dependent pathway
• however, response to agonists that activate signaling via the TRIF-dependent pathway is normal
• LPS-treated mice exhibit delayed recovery as determined by lower body weight and temperature compared with wild-type mice

homeostasis/metabolism
• in LPS-treated mice after 18 to 42 hours

growth/size/body
• in LPS-treated mice after 18 to 42 hours

hematopoietic system
• slightly greater frequency of peritoneal monocytes in LPS-treated mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory