Analysis Tools|
Allele Symbol Allele Name Allele ID |
Braftm2Cpri targeted mutation 2, Catrin Pritchard MGI:5440045 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mouse embryonic fibroblast treated with adenoviral-cre exhibit normal growth rate
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| N |
• mice treated intranasally with adenovirus-cre do not exhibit lung abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 70% of mice survive to adulthood with some mice lost after weaning
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• in most mice
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• 4-fold in most mice
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• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks
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• one mouse exhibits small intestinal adenoma at 79 weeks
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• predisposition in aged mice
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• including cataracts and watery eyes in some mice
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• facial dysmorphia
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• in some mice
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• facial dysmorphia
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• in some mice
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• in most mice
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• 4-fold in most mice
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• in some mice
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• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks
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• in some mice
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• one mouse exhibits small intestinal adenoma at 79 weeks
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• predisposition in aged mice
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• in most mice
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• 4-fold in most mice
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• predisposition in aged mice
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• in some mice
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in primary mouse embryonic fibroblasts treated with adenovirus-cre compared with wild-type cells although not as much as in cells heterozygous for Krastm4Tyj
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• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes
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• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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