Analysis Tools|
Allele Symbol Allele Name Allele ID |
Braftm2Cpri targeted mutation 2, Catrin Pritchard MGI:5440045 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mouse embryonic fibroblast treated with adenoviral-cre exhibit normal growth rate
|
| N |
• mice treated intranasally with adenovirus-cre do not exhibit lung abnormalities
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only 70% of mice survive to adulthood with some mice lost after weaning
|
|
• in most mice
|
|
• 4-fold in most mice
|
|
• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks
|
|
• one mouse exhibits small intestinal adenoma at 79 weeks
|
|
• predisposition in aged mice
|
|
• including cataracts and watery eyes in some mice
|
|
• facial dysmorphia
|
|
• in some mice
|
|
• facial dysmorphia
|
|
• in some mice
|
|
• in most mice
|
|
• 4-fold in most mice
|
|
• in some mice
|
|
• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks
|
|
• in some mice
|
|
• one mouse exhibits small intestinal adenoma at 79 weeks
|
|
• predisposition in aged mice
|
|
• in most mice
|
|
• 4-fold in most mice
|
|
• predisposition in aged mice
|
|
• in some mice
|
|
• in some mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in primary mouse embryonic fibroblasts treated with adenovirus-cre compared with wild-type cells although not as much as in cells heterozygous for Krastm4Tyj
|
|
• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes
|
|
• in mice infected with adenovirus cre
• however, mice do not exhibit increased lung tumor incidence compared with Krastm4Tyj heterozygotes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
