Phenotypes associated with this allele

• Allele Symbol: Bmal1^tm1.1Ljm
• Allele Name: targeted mutation 1.1, Louis J Muglia
• Allele ID: MGI:5440061
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmal1^tm1.1Ljm/Bmal1^tm1.1Ljm Tg(Mylk-cre)1Ljm/0	involves: C57BL/6	MGI:5440078
cn2	Bmal1^tm1.1Ljm/Bmal1^tm1.1Ljm Tmem163^Tg(ACTB-cre)2Mrt/0	involves: C57BL/6 * FVB/N	MGI:5440080

Genotype
MGI:5440078

cn1

• Allelic Composition: Bmal1^tm1.1Ljm/Bmal1^tm1.1Ljm; Tg(Mylk-cre)1Ljm/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal parturition ( J:188253 )

♀ • timing of parturition was affected; 64% of pregnant females compared to 92% of control females gave birth between 5 pm on D19 and 9 am on D19.5 of gestation

delayed parturition ( J:188253 )

♀ • 18% of pregnant females delivered later than controls (after D19.5)

early parturition ( J:188253 )

♀ • about 18% of pregnant females gave birth earlier than controls (before D19)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:188253 )

♀N • normal progesterone and contractile-associated protein levels were observed in non-gravid and gravid (on D16 and 19) females

Genotype
MGI:5440080

cn2

• Allelic Composition: Bmal1^tm1.1Ljm/Bmal1^tm1.1Ljm; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: C57BL/6 * FVB/N

behavior/neurological

decreased locomotor activity ( J:188253 )

• mice show lower activity overall compared to controls

abnormal circadian behavior ( J:188253 )

• mice are arrhythmic in constant darkness whereas cre-negative floxed mice are rhythmic under 12-12h light dark conditons and constant darkness