Phenotypes associated with this allele

• Allele Symbol: Kansl1/Mapt^tm1.1Cole
• Allele Name: targeted mutation 1.1, Michael Coleman
• Allele ID: MGI:5440076
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kansl1/Mapt^tm1.1Cole/Kansl1/Mapt^tm1.1Cole	involves: C57BL/6 * C57BL/6J * C57BL/6JOlaHsd	MGI:5440094

Genotype
MGI:5440094

hm1

• Allelic Composition: Kansl1/Mapt^tm1.1Cole/Kansl1/Mapt^tm1.1Cole
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6JOlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:188213 )

N • mice exhibit normal olfactory memory

hyperactivity ( J:188213 )

• in 22 to 28 month old mice

nervous system

nervous system phenotype ( J:188213 )

N • up to 30 to 32 months, mice do not exhibit tau histopathology (aggregations)

abnormal axonal transport ( J:188213 )

• young mice exhibit an increase in anterograde flux of mitochondria in the tibial nerve axons but a decline in old age

• however, retrograde transport is normal