All Phenotypes Gt(ROSA)26Sor<tm1(Ctnnb1)Kem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}
targeted mutation 1, Rolf Kemler
MGI:5440173

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440184
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440185
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA	MGI:5440177
cn4	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Cdx1-cre)23Kem/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	MGI:5440180
cn5	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Cdx1-cre)23Kem/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	MGI:5440181
cn6	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Zp3-cre)93Knw/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:5440176
cn7	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J	MGI:5440183
cn8	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J	MGI:5440182

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2.1Kem mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Tg(Foxn1-cre)1Tbo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:187739 )

N	• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

sparse hair ( J:187739 )

• thinner but continuous coat

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:187739 )

N	• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

focal hair loss ( J:187739 )

• broad stripes of hair loss are seen

• loss is followed by regrowth

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2.1Kem mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem} mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal germ layer development ( J:187739 )

• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium

failure to gastrulate ( J:187739 )

• expression analysis indicates failure to gastrulate

abnormal embryonic tissue morphology ( J:187739 )

• formation of proper embryonic structures is incomplete

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Cdx1-cre)23Kem/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

caudal body truncation ( J:187739 )

• at E14.5 embryos consist of a head attached to internal organs including lung, liver and intestine while the urogenital system and mesoderm-derived tissues making up the body wall are highly underdeveloped or absent

truncated tail bud ( J:187739 )

• truncated tail bud region at E9.5

limbs/digits/tail

truncated tail bud ( J:187739 )

• truncated tail bud region at E9.5

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Cdx1-cre)23Kem/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:187739 )

• develop until birth but do not survive

embryo

embryo phenotype ( J:187739 )

N	• at E9.5 the length of tail buds are similar to controls

abnormal neural tube morphology ( J:187739 )

• abnormally folded distally at E9.5

open neural tube ( J:187739 )

renal/urinary system

persistent cloaca ( J:187739 )

• at E14.5

small kidney ( J:187739 )

• at E14.5

reproductive system

persistent cloaca ( J:187739 )

• at E14.5

abnormal sex gland morphology ( J:187739 )

• small gonads at E14.5

limbs/digits/tail

abnormal digit morphology ( J:187739 )

• deformed shortened forelimb digits vertebrae at E18.5

fused phalanges ( J:187739 )

• at E18.5

brachydactyly ( J:187739 )

• at E18.5

abnormal hindlimb morphology ( J:187739 )

• at E18.5 in rare cases some rudimentary upper hindlimb bones are present

absent hindlimb ( J:187739 )

• at E14.5

absent tail ( J:187739 )

• at E14.5

skeleton

fused phalanges ( J:187739 )

• at E18.5

abnormal rib morphology ( J:187739 )

• deformed shortened fused ribs at E18.5

rib fusion ( J:187739 )

• at E18.5

short ribs ( J:187739 )

• at E18.5

abnormal vertebrae morphology ( J:187739 )

• deformed shortened fused vertebrae at E18.5

small vertebrae ( J:187739 )

• at E18.5

vertebral fusion ( J:187739 )

• at E18.5

digestive/alimentary system

persistent cloaca ( J:187739 )

• at E14.5

nervous system

abnormal neural tube morphology ( J:187739 )

• abnormally folded distally at E9.5

open neural tube ( J:187739 )

endocrine/exocrine glands

small adrenal glands ( J:187739 )

• at E14.5

abnormal sex gland morphology ( J:187739 )

• small gonads at E14.5

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Zp3-cre)93Knw/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

embryo

abnormal germ layer development ( J:187739 )

failure to gastrulate ( J:187739 )

• expression analysis indicates failure to gastrulate

abnormal embryonic tissue morphology ( J:187739 )

• formation of proper embryonic structures is incomplete

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:187739 )

nervous system

abnormal brain morphology ( J:187739 )

• brain defects

craniofacial

abnormal craniofacial morphology ( J:187739 )

• impaired morphogenesis of craniofacial structures

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:187739 )

• die within hours of birth probably because of an inability to feed

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