Phenotypes associated with this allele

• Allele Symbol: Fhod3^tm1Hsum
• Allele Name: targeted mutation 1, Hideki Sumimoto
• Allele ID: MGI:5440613
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhod3^tm1Hsum/Fhod3^tm1Hsum	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5440664
cx2	Fhod3^tm1Hsum/Fhod3^+ Tg(Myh6-Fhod3*I1127A)#Hsum/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5440665

Genotype
MGI:5440664

hm1

• Allelic Composition: Fhod3^tm1Hsum/Fhod3^tm1Hsum
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:187358 )

• all mice die between E11.5 and E12.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:187358 )

• not well formed

abnormal myocardial trabeculae morphology ( J:187358 )

• retardation or arrest of trabecular formation at E10.5

abnormal heart development ( J:187358 )

• premyofibrils fail to mature

• however, transgenic expression rescues cardiac defects

delayed heart looping ( J:187358 )

• at E9.5

pericardial effusion ( J:187358 )

• all mice die between E11.5 and E12.5

decreased heart ventricle muscle contractility ( J:187358 )

• despite spontaneous heart beats at E8-E8.5, ventricular walls are hypokinetic at E9.5

abnormal heartbeat ( J:187358 )

• despite spontaneous heart beats at E8-E8.5, ventricular walls are hypokinetic at E9.5

absent heartbeat ( J:187358 )

• by E10.5

growth/size/body

embryonic growth retardation ( J:187358 )

• at E10.5

decreased embryo size ( J:187358 )

• at E9.5

homeostasis/metabolism

pericardial effusion ( J:187358 )

• all mice die between E11.5 and E12.5

muscle

abnormal myocardial trabeculae morphology ( J:187358 )

• retardation or arrest of trabecular formation at E10.5

decreased heart ventricle muscle contractility ( J:187358 )

• despite spontaneous heart beats at E8-E8.5, ventricular walls are hypokinetic at E9.5

embryo

abnormal vitelline vasculature morphology ( J:187358 )

• not well formed

embryonic growth retardation ( J:187358 )

• at E10.5

decreased embryo size ( J:187358 )

• at E9.5

Genotype
MGI:5440665

cx2

• Allelic Composition: Fhod3^tm1Hsum/Fhod3⁺; Tg(Myh6-Fhod3*I1127A)#Hsum/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

mortality/aging

postnatal lethality, complete penetrance ( J:187358 )

• all mice die by 3 weeks after birth

preweaning lethality, incomplete penetrance ( J:187358 )

• fewer than expected mice are present at P8

cardiovascular system

abnormal myocardium layer morphology ( J:187358 )

• at P7, ventricular walls lack the non-compact layer of myocardium

abnormal heart development ( J:187358 )

• premyofibrils fail to mature

thin ventricular wall ( J:187358 )

• at P7

dilated heart ( J:187358 )

• at P7

muscle

abnormal myocardium layer morphology ( J:187358 )

• at P7, ventricular walls lack the non-compact layer of myocardium