All Phenotypes Tg(Myh6-Fhod3*I1127A)#Hsum MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Myh6-Fhod3*I1127A)#Hsum
transgene insertion, Hideki Sumimoto
MGI:5440647

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fhod3^tm1Hsum/Fhod3⁺ Tg(Myh6-Fhod3*I1127A)#Hsum/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5440665

Allelic Composition	Fhod3^tm1Hsum/Fhod3⁺ Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhod3^tm1Hsum mutation (0 available); any Fhod3 mutation (92 available)
Tg(Myh6-Fhod3*I1127A)#Hsum mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:187358 )

• all mice die by 3 weeks after birth

preweaning lethality, incomplete penetrance ( J:187358 )

• fewer than expected mice are present at P8

cardiovascular system

abnormal myocardium layer morphology ( J:187358 )

• at P7, ventricular walls lack the non-compact layer of myocardium

abnormal heart development ( J:187358 )

• premyofibrils fail to mature

thin ventricular wall ( J:187358 )

• at P7

dilated heart ( J:187358 )

• at P7

muscle

abnormal myocardium layer morphology ( J:187358 )

• at P7, ventricular walls lack the non-compact layer of myocardium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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