Phenotypes associated with this allele

• Allele Symbol: Plin5^tm1Tosu
• Allele Name: targeted mutation 1, Takashi Osumi
• Allele ID: MGI:5440666
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plin5^tm1Tosu/Plin5^tm1Tosu	involves: C57BL/6JJcl	MGI:5440671

Genotype
MGI:5440671

hm1

• Allelic Composition: Plin5^tm1Tosu/Plin5^tm1Tosu
• Genetic Background: involves: C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of lipid droplets in Plin5^tm1Tosu/Plin5^tm1Tosu hearts

homeostasis/metabolism

increased fatty acid oxidation ( J:188390 )

• enhanced in cardiomyocytes

increased oxygen consumption ( J:188390 )

• during the dark period

abnormal lipid level ( J:188390 )

• fed and fasted mice lack lipid droplets in the heart

increased circulating free fatty acids level ( J:188390 )

• 1.4-fold increase in nonesterified fatty acid in fasted mice

increased liver free fatty acids level ( J:188390 )

• in fasted mice

decreased fatty acids level ( J:188390 )

• in the heart

decreased liver free fatty acids level ( J:188390 )

• in fed mice

increased liver triglyceride level ( J:188390 )

• in fasted mice

decreased triglyceride level ( J:188390 )

• in the brown adipose tissue of fed mice

decreased cardiac muscle triglyceride level ( J:188390 )

• in the heart in fed and fasted mice

decreased liver triglyceride level ( J:188390 )

• in fed mice

cardiovascular system

decreased cardiac muscle triglyceride level ( J:188390 )

• in the heart in fed and fasted mice

abnormal heart ventricle morphology ( J:188390 )

• enlarged end-disatolic dimension and end-systolic dimension in aged mice

decreased cardiac muscle contractility ( J:188390 )

• reduced fractional shortening in aged mice

behavior/neurological

hyperactivity ( J:188390 )

• during the dark period

cellular

increased fatty acid oxidation ( J:188390 )

• enhanced in cardiomyocytes

oxidative stress ( J:188390 )

• in the heart

liver/biliary system

decreased liver free fatty acids level ( J:188390 )

• in fed mice

increased liver free fatty acids level ( J:188390 )

• in fasted mice

decreased liver triglyceride level ( J:188390 )

• in fed mice

increased liver triglyceride level ( J:188390 )

• in fasted mice

muscle

decreased cardiac muscle triglyceride level ( J:188390 )

• in the heart in fed and fasted mice

decreased cardiac muscle contractility ( J:188390 )

• reduced fractional shortening in aged mice