Phenotypes associated with this allele

• Allele Symbol: Fstl1^tm1Nju
• Allele Name: targeted mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:5440890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fstl1^tm1Nju/Fstl1^tm1Nju Tg(Scn10a-cre)1Rkun/0	involves: 129 * C57BL/6 * DBA	MGI:5440896

Genotype
MGI:5440896

cn1

• Allelic Composition: Fstl1^tm1Nju/Fstl1^tm1Nju; Tg(Scn10a-cre)1Rkun/0
• Genetic Background: involves: 129 * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:188549 )

• small dorsal root ganglion neurons have a reduction in the number of FSTL1-immunoreactive vesicles

abnormal action potential ( J:188549 )

• firing rates are elevated in wide-dynamic range neurons and both innocuous (pressure) and noxious (pinch) stimuli induce a similar increase in firing rate

increased excitatory postsynaptic current frequency ( J:188549 )

• the baseline of spontaneous excitatory postsynaptic current frequency in lamina II neurons is elevated

• the K+ induced frequency is increased

behavior/neurological

hyperresponsive to tactile stimuli ( J:188549 )

• reduced response threshold to von Frey mechanical stimuli applied to the hindpaw

decreased chemical nociceptive threshold ( J:188549 )

• display exaggerated responses in both first and second phases of the nociceptive reaction after intradermal injection of 0.5% formalin

decreased thermal nociceptive threshold ( J:188549 )

• reduced response latencies during radiant heat testing