Phenotypes associated with this allele

• Allele Symbol: Fstl1^tm1.1Nju
• Allele Name: targeted mutation 1.1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:5440894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fstl1^tm1.1Nju/Fstl1^tm1.1Nju	involves: 129 * C57BL/6 * FVB/N	MGI:5440895

Genotype
MGI:5440895

hm1

• Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney pelvis morphology ( J:187117 )

• dilated at E17.5

kidney papillary atrophy ( J:187117 )

• at E17.5

hydronephrosis ( J:187117 )

• profound at birth

• detectable at E17.5 but not at E15.5 or E16.5

small kidney ( J:187117 )

• at E17.5

abnormal ureter morphology ( J:187117 )

• at E17.0 the ureters are dilated, convoluted, fluid-filled and increased in length

• subepithelial ureteral mesenchymal cells are absent at E16.5 - E18.5

abnormal ureter development ( J:187117 )

• decrease in proliferation of the ureteric epithelium at E15.5

abnormal ureter urothelium morphology ( J:187117 )

• thinner layers of urothelium and mesenchyme at E17.0

dilated ureter ( J:187117 )

• at E16.0

• more severe in the proximal region than in the distal region

hydroureter ( J:187117 )

• profound at birth

• prominent and bilateral at E17.5

ureter stenosis ( J:187117 )

• the very distal segment of the ureter is extremely narrow and the distance between the two ureteral orifices is significantly shorter compared to controls at E15.5 and E16.5