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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elavl3tm1.1Rbd
targeted mutation 1.1, Robert B Darnell
MGI:5440933
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Elavl3tm1.1Rbd/Elavl3tm1.1Rbd either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) MGI:5440962
hm2
 		Elavl3tm1.1Rbd/Elavl3tm1.1Rbd involves: 129 * C57BL/6 MGI:5440960
hm3
 		Elavl3tm1.1Rbd/Elavl3tm1.1Rbd involves: 129 * CD-1 MGI:5440961
ht4
 		Elavl3tm1.1Rbd/Elavl3+ either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) MGI:5440964
cx5
 		Elavl3tm1.1Rbd/Elavl3tm1.1Rbd
Elavl4tm1Okn/Elavl4tm1Okn 		either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) MGI:5440963


Genotype
MGI:5440962
hm1
Allelic
Composition		 Elavl3tm1.1Rbd/Elavl3tm1.1Rbd
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:188326 )
N
• tail-twitch on a hot plate is normal
impaired coordination ( J:188326 )
• in young adult mice
nonconvulsive seizures ( J:188326 )
• non-convulsive electrographic seizures
abnormal spike wave discharge ( J:188326 )
• mice exhibit severe continuous bilateral synchronous sharp cortical spike discharges

nervous system
nonconvulsive seizures ( J:188326 )
• non-convulsive electrographic seizures
abnormal spike wave discharge ( J:188326 )
• mice exhibit severe continuous bilateral synchronous sharp cortical spike discharges
abnormal brain wave pattern ( J:188326 )
• abnormal cortical hypersynchronization




Genotype
MGI:5440960
hm2
Allelic
Composition		 Elavl3tm1.1Rbd/Elavl3tm1.1Rbd
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:188326 )
• Background Sensitivity: fewer than expected mice are produced from heterozygous parents unlike mice on a mixed background with CD-1




Genotype
MGI:5440961
hm3
Allelic
Composition		 Elavl3tm1.1Rbd/Elavl3tm1.1Rbd
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:188326 )
N
• Background Sensitivity: mice are produced in normal Mendelian ratios unlike on a C57BL/6 background




Genotype
MGI:5440964
ht4
Allelic
Composition		 Elavl3tm1.1Rbd/Elavl3+
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:188326 )
• mice exhibit continuous bilateral synchronous sharp cortical spike discharges sometimes accompanied by brief afterdischarges

nervous system
abnormal spike wave discharge ( J:188326 )
• mice exhibit continuous bilateral synchronous sharp cortical spike discharges sometimes accompanied by brief afterdischarges
abnormal brain wave pattern ( J:188326 )
• abnormal cortical hypersynchronization




Genotype
MGI:5440963
cx5
Allelic
Composition		 Elavl3tm1.1Rbd/Elavl3tm1.1Rbd
Elavl4tm1Okn/Elavl4tm1Okn
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
Elavl4tm1Okn mutation (0 available); any Elavl4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:188326 )
• mice die several hours after birth

homeostasis/metabolism
decreased glutamic acid level ( J:188326 )
• glutamate levels are reduced in the cortical tissue




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory