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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsk3btm2138.1Arte
targeted mutation 2138.1, TaconicArtemis
MGI:5440976
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsk3btm2138.1Arte/Gsk3btm2138.1Arte C57BL/6-Gsk3btm2138.1Arte MGI:5440997


Genotype
MGI:5440997
hm1
Allelic
Composition		 Gsk3btm2138.1Arte/Gsk3btm2138.1Arte
Genetic
Background		 C57BL/6-Gsk3btm2138.1Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm2138.1Arte mutation (0 available); any Gsk3b mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal Wallerian degeneration ( J:188272 )
• following NGF deprivation, application of 3MB-PP1 to the cell body compartment of cultured dorsal root ganglion inhibits axon degeneration unlike in wild-type cultures
• however, axon degeneration is not blocked when 3MB-PP1 is applied only to the axon compartment

nervous system
abnormal Wallerian degeneration ( J:188272 )
• following NGF deprivation, application of 3MB-PP1 to the cell body compartment of cultured dorsal root ganglion inhibits axon degeneration unlike in wild-type cultures
• however, axon degeneration is not blocked when 3MB-PP1 is applied only to the axon compartment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory