Phenotypes associated with this allele

• Allele Symbol: Ano6^tm1.2Lyj
• Allele Name: targeted mutation 1.2, Lily Yeh Jan
• Allele ID: MGI:5441003
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ano6^tm1.2Lyj/Ano6^tm1.2Lyj	involves: 129X1/SvJ * C57BL/6	MGI:5441048

Genotype
MGI:5441048

hm1

• Allelic Composition: Ano6^tm1.2Lyj/Ano6^tm1.2Lyj
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:188263 )

• megakaryocytes fail to exhibit a calcium- and voltage-sensitive outward rectifying current unlike wild-type cells

abnormal platelet physiology ( J:188263 )

• platelets exhibit impaired procoagulant activity

homeostasis/metabolism

abnormal platelet physiology ( J:188263 )

• platelets exhibit impaired procoagulant activity

decreased susceptibility to induced thrombosis ( J:188263 )

• mice treated with ferric chloride to induce occlusive thrombus formation fail to exhibit occlusion unlike wild-type mice

increased bleeding time ( J:188263 )