Analysis Tools
adipose tissue
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• mice fed a high-fat diet show an increase in adipose tissue mass
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• mice fed a high-fat diet show an increase in the total number of myeloid subpopulations like neutrophils and F4/80+ adipose tissue macrophages within the visceral adipose tissue without alterations in the frequency of M1- or M2-like adipose tissue macrophages
• mice fed a high-fat diet show an increase in infiltration of lymphoid cells into visceral adipose tissue, with increased numbers of both T and B cells
• mice fed a high-fat diet exhibit an increase in visceral adipose tissue leukocytosis
• however, mice fed a high-fat diet show normal lymphoid organ T cell homeostasis
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behavior/neurological
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• mice fed a high-fat diet show a trend toward reduced activity
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growth/size/body
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• mice fed a high-fat diet show an increase in body weight, fat mass, and fat-free mass compared to wild-type mice
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hematopoietic system
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• obese mice (fed the high-fat diet) show a unique population of visceral adipose tissue T cells that are larger in size
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homeostasis/metabolism
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• mice fed a high-fat diet show a trend toward reduced total energy expenditure when controlled for fat mass, fat-free mass, and activity and significantly reduced resting energy expenditure
• however, no differences are seen in food intake on a high-fat diet compared to controls
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• mice fed a high-fat diet show an increase in body weight, fat mass, and fat-free mass compared to wild-type mice
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• mice fed a high-fat diet exhibit glucose intolerance
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• mice fed a high-fat diet exhibit increased insulin resistance
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• mice fed a high-fat diet show an increase in total cholesterol
• however, triglycerides and serum leptin levels are not affected in high-fat diet fed mice
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immune system
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• mice fed a high-fat diet show an increase in the total number of myeloid subpopulations like neutrophils and F4/80+ adipose tissue macrophages within the visceral adipose tissue without alterations in the frequency of M1- or M2-like adipose tissue macrophages
• mice fed a high-fat diet show an increase in infiltration of lymphoid cells into visceral adipose tissue, with increased numbers of both T and B cells
• mice fed a high-fat diet exhibit an increase in visceral adipose tissue leukocytosis
• however, mice fed a high-fat diet show normal lymphoid organ T cell homeostasis
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• obese mice (fed the high-fat diet) show a unique population of visceral adipose tissue T cells that are larger in size
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liver/biliary system
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• mice fed a high-fat diet develop hepatic steatosis
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