Phenotypes associated with this allele

• Allele Symbol: Mis18a^tm1.2Kiik
• Allele Name: targeted mutation 1.2, Keun Il Kim
• Allele ID: MGI:5441069
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mis18a^tm1.2Kiik/Mis18a^tm1.2Kiik	B6(129S)-Mis18a^tm1.2Kiik	MGI:5441071
cn2	Mis18a^tm1.1Kiik/Mis18a^tm1.2Kiik	B6(129S)-Mis18a^tm1.1Kiik/Mis18a^tm1.2Kiik	MGI:5441072

Genotype
MGI:5441071

hm1

• Allelic Composition: Mis18a^tm1.2Kiik/Mis18a^tm1.2Kiik
• Genetic Background: B6(129S)-Mis18a^tm1.2Kiik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation ( J:188023 )

• mice die between E3.5 and E9.5

cellular

abnormal mitosis ( J:188023 )

• in E4.5 embryos, cells exhibit mitotic defects including inappropriate chromosome condensation, misaligned chromosomes and microtubules, defective anaphase bridges, and lagging chromosomes in telophase resulting in fragmented chromosomes

increased embryonic tissue cell apoptosis ( J:188023 )

• in E5.0 embryos

decreased inner cell mass proliferation ( J:188023 )

• the inner cell mass of E3.5 embryos does not grow well

abnormal DNA methylation ( J:188023 )

• decreased in mouse embryonic fibroblasts

embryo

increased embryonic tissue cell apoptosis ( J:188023 )

• in E5.0 embryos

decreased inner cell mass proliferation ( J:188023 )

• the inner cell mass of E3.5 embryos does not grow well

inner cell mass degeneration ( J:188023 )

Genotype
MGI:5441072

cn2

• Allelic Composition: Mis18a^tm1.1Kiik/Mis18a^tm1.2Kiik
• Genetic Background: B6(129S)-Mis18a^tm1.1Kiik/Mis18a^tm1.2Kiik

cellular

abnormal mitosis ( J:188023 )

• following cre-expression, mouse embryonic fibroblasts exhibit defects in chromosome segregation and centromere organization

decreased fibroblast proliferation ( J:188023 )

• following cre-expression