Phenotypes associated with this allele

• Allele Symbol: Relb^tm1.1Fwei
• Allele Name: targeted mutation 1.1, Falk Weih
• Allele ID: MGI:5441212
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Relb^tm1.1Fwei/Relb^tm1.1Fwei Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:5441217
cn2	Relb^tm1.1Fwei/Relb^tm1.1Fwei Tg(Lck-cre)I57Jxm/0	involves: ICR	MGI:5441216

Genotype
MGI:5441217

cn1

• Allelic Composition: Relb^tm1.1Fwei/Relb^tm1.1Fwei; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:169863 )

N • mice exhibit normal numbers of IL17-producing thymic gamma-delta T cells

Genotype
MGI:5441216

cn2

• Allelic Composition: Relb^tm1.1Fwei/Relb^tm1.1Fwei; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: ICR

hematopoietic system

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system

immune system phenotype ( J:169863 )

N • alpha-beta Th17 cell differentiation is normal

abnormal gamma-delta T cell morphology ( J:169863 )

• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

decreased interleukin-17 secretion ( J:169863 )

• in the peritoneal cavity of E. coli-infected mice

• in TCRbeta+CD4+CD44^hi thymocytes

increased susceptibility to bacterial infection ( J:169863 )

• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice