Phenotypes associated with this allele

• Allele Symbol: Tg(Rho*G90D*A337V)202Sie
• Allele Name: transgene insertion 202, Paul A Sieving
• Allele ID: MGI:5441362
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rho^tm1Phm/Rho^+ Tg(Rho*G90D*A337V)202Sie/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:5441374
cx2	Rho^tm1Phm/Rho^+ Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:5441375
cx3	Rho^tm1Phm/Rho^tm1Phm Tg(Rho*G90D*A337V)202Sie/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:5441376
cx4	Rho^tm1Phm/Rho^tm1Phm Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:5441377
tg5	Tg(Rho*G90D*A337V)202Sie/0	involves: C57BL/6 * DBA	MGI:5441373

Genotype
MGI:5441374

cx1

• Allelic Composition: Rho^tm1Phm/Rho⁺; Tg(Rho*G90D*A337V)202Sie/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:188632 )

N • mice exhibit normal outer nuclear layer thickness, retinal outer segment length, photoreceptor numbers and rhodopsin complement

abnormal eye electrophysiology ( J:188632 )

• at 16 weeks, mice exhibit reduced maximal a-wave amplitude and increased a-wave threshold compared with Rho^tm1Phm heterozygotes

abnormal rod electrophysiology ( J:188632 )

• mice exhibit loss of rod sensitivity with rod photoreceptor desensitization and faster response time to peak compared with Rho^tm1Phm heterozygotes

• rods exhibit a partially light-adapted phenotype

Genotype
MGI:5441375

cx2

• Allelic Composition: Rho^tm1Phm/Rho⁺; Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

vision/eye

vision/eye phenotype ( J:188632 )

N • normal rod outer segments and minimal rod cell loss

abnormal eye electrophysiology ( J:188632 )

• at 24 weeks, mice exhibit reduced maximal a- and b-wave amplitude and increased a- and b-wave threshold compared with Rho^tm1Phm heterozygotes

abnormal rod electrophysiology ( J:188632 )

• increased equivalent background light level

• rods exhibit a partially light-adapted phenotype

Genotype
MGI:5441376

cx3

• Allelic Composition: Rho^tm1Phm/Rho^tm1Phm; Tg(Rho*G90D*A337V)202Sie/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

vision/eye

vision/eye phenotype ( J:188632 )

N • mice develop outer segments unlike Rho^tm1Phm homozygotes

retina photoreceptor degeneration ( J:188632 )

• slower than in Rho^tm1Phm homozygotes

thin retina outer nuclear layer ( J:188632 )

• 60% of normal at 14 weeks

nervous system

retina photoreceptor degeneration ( J:188632 )

• slower than in Rho^tm1Phm homozygotes

Genotype
MGI:5441377

cx4

• Allelic Composition: Rho^tm1Phm/Rho^tm1Phm; Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

vision/eye

vision/eye phenotype ( J:188632 )

N

retina photoreceptor degeneration ( J:188632 )

thin retina outer nuclear layer ( J:188632 )

abnormal eye electrophysiology ( J:188632 )

nervous system

retina photoreceptor degeneration ( J:188632 )

Genotype
MGI:5441373

tg5

• Allelic Composition: Tg(Rho*G90D*A337V)202Sie/0
• Genetic Background: involves: C57BL/6 * DBA

vision/eye

vision/eye phenotype ( J:188632 )

N • unlike other models of nightblindness, mice do not exhibit loss of rods

abnormal rod electrophysiology ( J:188632 )

• reduced dark-adapted b-wave threshold without rod degeneration

• rod sensitivity is depressed and required higher flash intensity

• for half maximal responses, the time to pear is faster than for wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital stationary night blindness autosomal dominant 1		DOID:0110862	OMIM:610445	J:188632