Phenotypes associated with this allele

• Allele Symbol: Xbp1^tm3Glm
• Allele Name: targeted mutation 3, Laurie H Glimcher
• Allele ID: MGI:5441521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Xbp1^tm3Glm/Xbp1^tm3Glm Tg(Vil1-cre/ERT2)23Syr/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5441534

Genotype
MGI:5441534

cn1

• Allelic Composition: Xbp1^tm3Glm/Xbp1^tm3Glm; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased Paneth cell number ( J:188627 )

• reduced numbers in tamoxifen-treated mice

decreased small intestinal villus size ( J:188627 )

• in tamoxifen-treated mice

abnormal intestine physiology ( J:188627 )

• increased apoptosis at the base of crypts (Paneth cells) and in villous epithelium (goblet cells) in tamoxifen-treated mice

small intestinal inflammation ( J:188627 )

• focal enteritis in 4 of 9 tamoxifen-treated mice ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas

• enteritis in 7 of 18 tamoxifen-treated mice

immune system

small intestinal inflammation ( J:188627 )

• focal enteritis in 4 of 9 tamoxifen-treated mice ranges in severity from lamina propria polymorphpnuclear infiltration to crypt abscesses and ulceration without granulomas

• enteritis in 7 of 18 tamoxifen-treated mice

cellular

increased apoptosis ( J:188627 )

• at the base of crypts (Paneth cells) and in villous epithelium (goblet cells) in tamoxifen-treated mice

endocrine/exocrine glands

decreased Paneth cell number ( J:188627 )

• reduced numbers in tamoxifen-treated mice