Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Tag*,-flpe)#Gne
• Allele Name: transgene insertion, Genentech
• Allele ID: MGI:5441546
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Ins2-Tag*,-flpe)#Gne/0	involves: C57BL/6J	MGI:5441547
cn2	Tg(Ins2-Tag*,-flpe)#Gne/0	Not Specified	MGI:5441548

Genotype
MGI:5441547

cn1

• Allelic Composition: Tg(Ins2-Tag*,-flpe)#Gne/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187012 )

• mean and median survival are 13.7 weeks

neoplasm

increased pancreas tumor incidence ( J:187012 )

• angiogenic islets are detected from 7 weeks of age

• solid tumors are detected starting at about 10 weeks of age

• mean tumor burden increases linearly with age

• anti-VEGF, but not sunitinib, treatment significantly decreases the number of grossly visible solid tumors after 21 days of treatment

increased insulinoma incidence ( J:187012 )

increased pancreatic islet cell carcinoma incidence ( J:187012 )

• micro- and macro-invasive carcinomas are detected

endocrine/exocrine glands

abnormal pancreas morphology ( J:187012 )

• hemorrhagic spots are seen in the pancreas starting at about 7 weeks of age

increased pancreas tumor incidence ( J:187012 )

• angiogenic islets are detected from 7 weeks of age

• solid tumors are detected starting at about 10 weeks of age

• mean tumor burden increases linearly with age

• anti-VEGF, but not sunitinib, treatment significantly decreases the number of grossly visible solid tumors after 21 days of treatment

increased insulinoma incidence ( J:187012 )

increased pancreatic islet cell carcinoma incidence ( J:187012 )

• micro- and macro-invasive carcinomas are detected

cardiovascular system

internal hemorrhage ( J:187012 )

• hemorrhagic spots are seen in the pancreas starting at about 7 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:187012

Genotype
MGI:5441548

cn2

• Allelic Composition: Tg(Ins2-Tag*,-flpe)#Gne/0
• Genetic Background: Not Specified

neoplasm

increased pancreatic islet cell carcinoma incidence ( J:188693 )

• shows the same temporal progression of multistage islet cell carcinogenesis as mice carrying Tg(RIP1-Tag)2Dh

• early intervention (before 10 weeks of age) with anti-VEGF treatment results in a dramatic reduction of tumors and decreased tumor microvascular density

endocrine/exocrine glands

increased pancreatic islet cell carcinoma incidence ( J:188693 )

• shows the same temporal progression of multistage islet cell carcinogenesis as mice carrying Tg(RIP1-Tag)2Dh

• early intervention (before 10 weeks of age) with anti-VEGF treatment results in a dramatic reduction of tumors and decreased tumor microvascular density

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:188693