Phenotypes associated with this allele

• Allele Symbol: Rptor^tm1Ahir
• Allele Name: targeted mutation 1, Atsushi Hirao
• Allele ID: MGI:5441589
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rptor^tm1Ahir/Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz/0	B6.Cg-Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz	MGI:5441610

Genotype
MGI:5441610

cn1

• Allelic Composition: Rptor^tm1Ahir/Rptor^tm1Ahir; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: B6.Cg-Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:188676 )

• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice

increased dendritic cell number ( J:188676 )

• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells

• however, the total number of conventional and plasmacytoid dendritic cells is normal

digestive/alimentary system

decreased colon length ( J:188676 )

• exaggerated reduction of colon length in DSS-treated mice

increased susceptibility to induced colitis ( J:188676 )

• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice

growth/size/body

increased susceptibility to weight loss ( J:188676 )

• exaggerated in DSS-treated mice

hematopoietic system

increased dendritic cell number ( J:188676 )

• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells

• however, the total number of conventional and plasmacytoid dendritic cells is normal