Phenotypes associated with this allele

• Allele Symbol: Peli3^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5441750
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Peli3^tm1.1Arte/Peli3^tm1.1Arte	involves: C57BL/6NTac	MGI:5441752

Genotype
MGI:5441752

hm1

• Allelic Composition: Peli3^tm1.1Arte/Peli3^tm1.1Arte
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:188556 )

• about 60% of mice survive a high dose (250 PFU) infection with encephalomyocarditis virus (EMCV) that is lethal in 100% of wild-type mice by 7 days post infection

• all mice survive a lower dose (50 PFU) infection with EMCV that causes 50% lethality in wild-type mice by 10 days post infection

cellular

abnormal cell physiology ( J:188556 )

• increase in the efficacy of poly(I:C) to induce type 1 interferon and CXCL10 in MEFs

immune system

abnormal macrophage cytokine production ( J:188556 )

• increase in the efficacy of poly(I:C) to induce IFNB, CXCL10, and IFNA in bone marrow derived macrophages

abnormal dendritic cell physiology ( J:188556 )

• increase in the efficacy of poly(I:C) to induce type 1 interferon and CXCL10 in myeloid dendritic cells

decreased susceptibility to Picornaviridae infection ( J:188556 )

• an increased heart/body weight ratio characteristic of EMCV infections and alterations of heart morphology seen in wild-type controls are not seen at low doses of infection

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:188556 )

• about 60% of mice survive a high dose (250 PFU) infection with encephalomyocarditis virus (EMCV) that is lethal in 100% of wild-type mice by 7 days post infection

• all mice survive a lower dose (50 PFU) infection with EMCV that causes 50% lethality in wild-type mice by 10 days post infection

hematopoietic system

abnormal macrophage cytokine production ( J:188556 )

• increase in the efficacy of poly(I:C) to induce IFNB, CXCL10, and IFNA in bone marrow derived macrophages