About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbk1M1Btlr
mutation 1, Bruce Beutler
MGI:5442100
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbk1M1Btlr/Tbk1M1Btlr involves: C57BL/6J MGI:5442119
ht2
 		Tbk1M1Btlr/Tbk1+ involves: C57BL/6J MGI:5442118


Genotype
MGI:5442119
hm1
Allelic
Composition		 Tbk1M1Btlr/Tbk1M1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1M1Btlr mutation (1 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5442118
ht2
Allelic
Composition		 Tbk1M1Btlr/Tbk1+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbk1M1Btlr mutation (1 available); any Tbk1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides
abnormal interferon secretion ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides

hematopoietic system
abnormal macrophage physiology ( J:188770 )
• isolated peritoneal macrophages produce reduced amounts of type I interferon (IFN) in response to transfection with dsDNA oligonucleotides




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory