About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec63tm1Som
targeted mutation 1, Stefan Somlo
MGI:5442171
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0 		involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5442324
cn2
 		Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442321
cn3
 		Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442322
cn4
 		Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J MGI:5442320
cn5
 		Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * ICR MGI:5442319


Genotype
MGI:5442324
cn1
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188763 )
• in mice treated with a high does tamoxifen induction regime

liver/biliary system
liver cyst ( J:188763 )
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype

growth/size/body
liver cyst ( J:188763 )
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype




Genotype
MGI:5442321
cn2
Allelic
Composition		 Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1Som mutation (0 available); any Pkd1 mutation (154 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased kidney apoptosis ( J:188763 )
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
increased kidney cell proliferation ( J:188763 )
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
kidney cyst ( J:188763 )
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
abnormal loop of Henle ascending limb thick segment morphology ( J:188763 )
• dilated to a lesser extent than collecting tubules

cellular
increased kidney apoptosis ( J:188763 )
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
increased kidney cell proliferation ( J:188763 )
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
increased kidney weight ( J:188763 )




Genotype
MGI:5442322
cn3
Allelic
Composition		 Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm2Som mutation (0 available); any Pkd2 mutation (85 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )




Genotype
MGI:5442320
cn4
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Tg(Pkd1)248Som mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:188763 )
• mild at P45

growth/size/body
kidney cyst ( J:188763 )
• mild at P45




Genotype
MGI:5442319
cn5
Allelic
Composition		 Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188763 )
• by P60 associated with kidney cysts

renal/urinary system
kidney cyst ( J:188763 )
• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype
abnormal loop of Henle ascending limb thick segment morphology ( J:188763 )
• dilated to a lesser extent than collecting tubules

homeostasis/metabolism

growth/size/body
kidney cyst ( J:188763 )
• collecting ducts form large cysts
• mild at P14, advanced at P30 and severe at P69
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory