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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sec63tm1Som
targeted mutation 1, Stefan Somlo
MGI:5442171
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5442324
cn2
Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442321
cn3
Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL MGI:5442322
cn4
Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J MGI:5442320
cn5
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * ICR MGI:5442319


Genotype
MGI:5442324
cn1
Allelic
Composition
Sec63tm1Som/Sec63tm1Som
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice treated with a high does tamoxifen induction regime

liver/biliary system
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype

growth/size/body
• bile duct-derived cysts in the liver beginning at P28 in tamoxifen-treated mice
• severe by 4 to 5 months in tamoxifen-treated mice
• expression of Tg(Pkd2)#Som expression does not rescue cystic liver phenotype
• however, expression of Tg(Pdk1)248Som rescues cystic liver phenotype




Genotype
MGI:5442321
cn2
Allelic
Composition
Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm1Som mutation (0 available); any Pkd1 mutation (154 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice
• dilated to a lesser extent than collecting tubules

cellular
• increased apoptosis in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• increased cell proliferation in cysts compared to in cysts from Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice

homeostasis/metabolism

growth/size/body
• more severe than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• collecting duct forms larger cysts than in Sec63tm1Som/Sec63tm1Som Tg(Cdh16-cre)91Igr mice
• cysts exhibit increased proliferation and apoptosis compared with cysts from Prkcshtm1Som/Prkcshtm1Som Tg(Cdh16-cre)91Igr mice




Genotype
MGI:5442322
cn3
Allelic
Composition
Pkd2tm2Som/Pkd2+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm2Som mutation (0 available); any Pkd2 mutation (85 available)
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system

homeostasis/metabolism

growth/size/body




Genotype
MGI:5442320
cn4
Allelic
Composition
Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Tg(Pkd1)248Som mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mild at P45

growth/size/body
• mild at P45




Genotype
MGI:5442319
cn5
Allelic
Composition
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by P60 associated with kidney cysts

renal/urinary system
• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype
• dilated to a lesser extent than collecting tubules

homeostasis/metabolism

growth/size/body
• mild at P14, advanced at P30 and severe at P69
• collecting ducts form large cysts
• however, expression of Tg(Pdk1)248Som slows development of cystic kidney phenotype





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory