Phenotypes associated with this allele

• Allele Symbol: Rev3l^tm1.1Kunk
• Allele Name: targeted mutation 1.1, Thomas A Kunkel
• Allele ID: MGI:5442607
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rev3l^tm1.1Kunk/Rev3l^tm1.1Kunk	involves: C57BL/6	MGI:5442609

Genotype
MGI:5442609

hm1

• Allelic Composition: Rev3l^tm1.1Kunk/Rev3l^tm1.1Kunk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:188723 )

N • B cells exhibit normal proliferation and class switch recombination when activated with LPS and IL4

abnormal somatic hypermutation frequency ( J:188723 )

• following immunization with NP-CGG in alum, splenic B cells exhibit reduced mutation frequency compared with wild-type cells

• Peyer's patch B cells exhibit increased accumulation of mutation at the intron downstream of rearranged V genes with altered patterns compared with wild-type cells

hematopoietic system

abnormal somatic hypermutation frequency ( J:188723 )

• following immunization with NP-CGG in alum, splenic B cells exhibit reduced mutation frequency compared with wild-type cells

• Peyer's patch B cells exhibit increased accumulation of mutation at the intron downstream of rearranged V genes with altered patterns compared with wild-type cells