Phenotypes associated with this allele

• Allele Symbol: Tph2^tm1Pasq
• Allele Name: targeted mutation 1, Massimo Pasqualetti
• Allele ID: MGI:5442736
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph2^tm1Pasq/Tph2^tm1Pasq	either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2^tm1Pasq	MGI:5442772
ht2	Tph2^tm1Pasq/Tph2^tm1.1Pasq	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5442773

Genotype
MGI:5442772

hm1

• Allelic Composition: Tph2^tm1Pasq/Tph2^tm1Pasq
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2^tm1Pasq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:188987 )

• although born in the expected ratios and grossly normal, 60% die within 3 weeks of birth on both a mixed and B6 background

• survivors have a normal life span and are fertile

growth/size/body

postnatal growth retardation ( J:188987 )

• a defect in growth rate is apparent a few days after birth

• slow recovery in weight of survivors after weaning

behavior/neurological

behavior/neurological phenotype ( J:188987 )

N • suckling is normal

Genotype
MGI:5442773

ht2

• Allelic Composition: Tph2^tm1Pasq/Tph2^tm1.1Pasq
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

nervous system

nervous system phenotype ( J:188987 )

N • normal density of serotonergic fibers in the cerebral cortex

abnormal paraventricular hypothalamic nucleus morphology ( J:188987 )

• reduced innervation, reduced fiber density

• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age

abnormal suprachiasmatic nucleus morphology ( J:188987 )

• reduced innervation, reduced fiber density

• arborization of fibers appears normal at birth but fiber density is significantly lower at 5 days of age

abnormal hippocampus morphology ( J:188987 )

• increased density of serotonergic fibers in the nucleus accumbens shell

• hyperinnervation in the hippocampus in all layers, particularly in the ventral portion of each layer