Allele Symbol Allele Name Allele ID |
Cdcp1tm1.2Moas targeted mutation 1.2, Mark Moasser MGI:5442763 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice did not exhibit gross morphologic or behavioral abnormalities
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• euthanized 12 weeks after tamoxifen-treatment
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• in tamoxifen-treated mice, particularly evident on the abdominal skin
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• tamoxifen-treated mice develop more severe epidermal disease (thick skin, hair loss and scaling) compared with control mice
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• 3.5-fold in tamoxifen-treated mice than in control mice
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• in tamoxifen-treated mice, particularly evident on the abdominal skin
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• in tamoxifen-treated mice
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• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
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• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
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• in tamoxifen-treated mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are euthanized at 12 weeks due to numerous large tumors
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• accelerated tumorigenesis compared with Tg(MMTV-PyVT)634Mul mice
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• with lung metastases
• at 12 weeks mice exhibit a 2.6-fold increase in the number of tumors per mouse with an average of 5.7-fold increase in total tumor burden compared with Tg(MMTV-PyVT)634Mul mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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