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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdcp1tm1.2Moas
targeted mutation 1.2, Mark Moasser
MGI:5442763
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas B6.129-Cdcp1tm1.2Moas MGI:5442765
hm2
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478600
cn3
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0
involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL MGI:5478604
cx4
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478601
cx5
Cdcp1tm1.2Moas/Cdcp1+
Tg(MMTV-PyVT)634Mul/0
involves: 129 * C57BL/6 * FVB/N * SJL MGI:5478603


Genotype
MGI:5442765
hm1
Allelic
Composition
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Genetic
Background
B6.129-Cdcp1tm1.2Moas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5478600
hm2
Allelic
Composition
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice did not exhibit gross morphologic or behavioral abnormalities




Genotype
MGI:5478604
cn3
Allelic
Composition
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• euthanized 12 weeks after tamoxifen-treatment

integument
• in tamoxifen-treated mice, particularly evident on the abdominal skin
• tamoxifen-treated mice develop more severe epidermal disease (thick skin, hair loss and scaling) compared with control mice
• 3.5-fold in tamoxifen-treated mice than in control mice
• in tamoxifen-treated mice, particularly evident on the abdominal skin
• in tamoxifen-treated mice

neoplasm
• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
• accelerated neoplasm development in tamoxifen-treated mice compared with control mice

behavior/neurological
• in tamoxifen-treated mice




Genotype
MGI:5478601
cx4
Allelic
Composition
Cdcp1tm1.2Moas/Cdcp1tm1.2Moas
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are euthanized at 12 weeks due to numerous large tumors

neoplasm
• accelerated tumorigenesis compared with Tg(MMTV-PyVT)634Mul mice
• at 12 weeks mice exhibit a 2.6-fold increase in the number of tumors per mouse with an average of 5.7-fold increase in total tumor burden compared with Tg(MMTV-PyVT)634Mul mice
• with lung metastases




Genotype
MGI:5478603
cx5
Allelic
Composition
Cdcp1tm1.2Moas/Cdcp1+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation (1 available); any Cdcp1 mutation (49 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• slight compared with Tg(MMTV-PyVT)634Mul mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory