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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myd88tm1Hlz
targeted mutation 1, Bernhard Holzmann
MGI:5442766
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myd88tm1Hlz/Myd88tm1Hlz B6.129P2-Myd88tm1Hlz MGI:5442779
cn2
 		Myd88tm1Hlz/Myd88tm1Hlz
Lyz2tm1(cre)Ifo/Lyz2+ 		B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo MGI:5442780


Genotype
MGI:5442779
hm1
Allelic
Composition		 Myd88tm1Hlz/Myd88tm1Hlz
Genetic
Background		 B6.129P2-Myd88tm1Hlz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Hlz mutation (2 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:188968 )
• in a model of septic peritonitis, mice exhibit an decrease in lung myeloperoxidase activity compared with control mice
decreased circulating interleukin-10 level ( J:188968 )
• in a CASP model of septic peritonitis
decreased circulating interleukin-12b level ( J:188968 )
• in a CASP model of septic peritonitis
decreased circulating interleukin-6 level ( J:188968 )
• in a CASP model of septic peritonitis
abnormal chemokine level ( J:188968 )
• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice
• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL2 and CXCL1 compared with control mice
• however, production of RANTES and CXCL10 is normal
decreased interleukin-10 secretion ( J:188968 )
• in the peritoneal lavage fluid in response to septic peritonitis
decreased interleukin-6 secretion ( J:188968 )
• absent in macrophage stimulated with Pam3Cys
• in the peritoneal lavage fluid in response to septic peritonitis
decreased tumor necrosis factor secretion ( J:188968 )
• absent in macrophage stimulated with Pam3Cys

homeostasis/metabolism
decreased circulating interleukin-10 level ( J:188968 )
• in a CASP model of septic peritonitis
decreased circulating interleukin-12b level ( J:188968 )
• in a CASP model of septic peritonitis
decreased circulating interleukin-6 level ( J:188968 )
• in a CASP model of septic peritonitis
decreased circulating alanine transaminase level ( J:188968 )
• in a model of septic peritonitis
decreased circulating aspartate transaminase level ( J:188968 )
• in a model of septic peritonitis
abnormal chemokine level ( J:188968 )
• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice
• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL2 and CXCL1 compared with control mice
• however, production of RANTES and CXCL10 is normal

hematopoietic system
decreased neutrophil cell number ( J:188968 )
• in a model of septic peritonitis, mice exhibit an decrease in lung myeloperoxidase activity compared with control mice




Genotype
MGI:5442780
cn2
Allelic
Composition		 Myd88tm1Hlz/Myd88tm1Hlz
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Myd88tm1Hlz mutation (2 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating chemokine level ( J:188968 )
• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice
increased circulating tumor necrosis factor level ( J:188968 )
• in a model of septic peritonitis
increased circulating alanine transaminase level ( J:188968 )
• in a model of septic peritonitis
increased circulating aspartate transaminase level ( J:188968 )
• in a model of septic peritonitis
decreased CXCL10 level ( J:188968 )
• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL10 compared with control mice
increased susceptibility to injury ( J:188968 )
• in a model of septic peritonitis, mice exhibit aggravated liver injury compared with control mice

immune system
immune system phenotype ( J:188968 )
N
• mice exhibit normal expression of cytokines and neutrophil accumulation in inflammatory models
abnormal circulating chemokine level ( J:188968 )
• in a CASP model of septic peritonitis, mice exhibit reduced circulating CXCL1 compared with control mice
increased circulating tumor necrosis factor level ( J:188968 )
• in a model of septic peritonitis
decreased CXCL10 level ( J:188968 )
• in response to septic peritonitis, the peritoneal lavage fluid contains less CXCL10 compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory