immune system
• Th1 cells exhibit reduced chemotaxis towards CXCL9 compared with wild-type cells
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• Th2 cells exhibit reduced chemotaxis towards CCL17 compared with wild-type cells
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• after S. mansoni challenge and restimulation with SEA
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• after S. mansoni challenge and restimulation with SEA
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• after S. mansoni challenge and restimulation with SEA
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• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis compared with wild-type mice
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• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis, a skewed Th2 response and increased cytokine (IL5, IL10 and IL13) secretion in lung draining mesenteric lymph nodes after restimulation with Schistosome egg Ag (SEA) compared with wild-type mice
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respiratory system
• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis compared with wild-type mice
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hematopoietic system
• Th1 cells exhibit reduced chemotaxis towards CXCL9 compared with wild-type cells
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• Th2 cells exhibit reduced chemotaxis towards CCL17 compared with wild-type cells
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