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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs16tm1.1Drue
targeted mutation 1.1, Kirk M Druey
MGI:5442790
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rgs16tm1.1Drue/Rgs16tm1.1Drue involves: C57BL/6 MGI:5442791


Genotype
MGI:5442791
hm1
Allelic
Composition		 Rgs16tm1.1Drue/Rgs16tm1.1Drue
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs16tm1.1Drue mutation (0 available); any Rgs16 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 1 physiology ( J:188966 )
• Th1 cells exhibit reduced chemotaxis towards CXCL9 compared with wild-type cells
abnormal T-helper 2 physiology ( J:188966 )
• Th2 cells exhibit reduced chemotaxis towards CCL17 compared with wild-type cells
increased interleukin-10 secretion ( J:188966 )
• after S. mansoni challenge and restimulation with SEA
increased interleukin-13 secretion ( J:188966 )
• after S. mansoni challenge and restimulation with SEA
increased interleukin-5 secretion ( J:188966 )
• after S. mansoni challenge and restimulation with SEA
granulomatous inflammation ( J:188966 )
• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis compared with wild-type mice
increased susceptibility to parasitic infection ( J:188966 )
• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis, a skewed Th2 response and increased cytokine (IL5, IL10 and IL13) secretion in lung draining mesenteric lymph nodes after restimulation with Schistosome egg Ag (SEA) compared with wild-type mice

respiratory system
pulmonary fibrosis ( J:188966 )
• after S. mansoni challenge, mice exhibit increased acute granulomatous lung fibrosis compared with wild-type mice

hematopoietic system
abnormal T-helper 1 physiology ( J:188966 )
• Th1 cells exhibit reduced chemotaxis towards CXCL9 compared with wild-type cells
abnormal T-helper 2 physiology ( J:188966 )
• Th2 cells exhibit reduced chemotaxis towards CCL17 compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory