Phenotypes associated with this allele

• Allele Symbol: Spns2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5442804
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spns2^tm1b(KOMP)Wtsi/Spns2^tm1b(KOMP)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Spns2^tm1b(KOMP)Wtsi/WtsiH	MGI:5757762
hm2	Spns2^tm1b(KOMP)Wtsi/Spns2^tm1b(KOMP)Wtsi	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N	MGI:5442812

Genotype
MGI:5757762

hm1

• Allelic Composition: Spns2^{tm1b(KOMP)Wtsi}/Spns2^{tm1b(KOMP)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Spns2^{tm1b(KOMP)Wtsi}/WtsiH
• Cell Lines: EPD0090_5_B04

Data Sources

IMPC Data for Spns2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent pinna reflex ( J:211773 )

IMPC - WTSI

trunk curl ( J:211773 )

IMPC - WTSI

cardiovascular system

cornea vascularization ( J:211773 )

IMPC - WTSI

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - WTSI

decreased leukocyte cell number ( J:211773 )

IMPC - WTSI

immune system

decreased leukocyte cell number ( J:211773 )

IMPC - WTSI

skeleton

decreased bone mineral content ( J:211773 )

♂

IMPC - WTSI

vision/eye

abnormal iris morphology ( J:211773 )

♀

IMPC - WTSI

abnormal cornea morphology ( J:211773 )

IMPC - WTSI

cornea vascularization ( J:211773 )

IMPC - WTSI

cornea opacity ( J:211773 )

IMPC - WTSI

narrow eye opening ( J:211773 )

IMPC - WTSI

Genotype
MGI:5442812

hm2

• Allelic Composition: Spns2^{tm1b(KOMP)Wtsi}/Spns2^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N
• Cell Lines: EPD0090_5_B04

immune system

decreased B cell number ( J:188933 )

• in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:188933 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:188933 )

• CD4+CD8- cells in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188933 )

• in the spleen

increased CD8-positive, alpha-beta T cell number ( J:188933 )

• CD4+CD8- cells in the thymus

hematopoietic system

decreased B cell number ( J:188933 )

• in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:188933 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:188933 )

• CD4+CD8- cells in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188933 )

• in the spleen

increased CD8-positive, alpha-beta T cell number ( J:188933 )

• CD4+CD8- cells in the thymus