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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcaptm1Rnk
targeted mutation 1, Ralph Knoll
MGI:5443850
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcaptm1Rnk/Tcaptm1Rnk Not Specified MGI:5443876
cx2
 		Tcaptm1Rnk/Tcaptm1Rnk
Tg(Myh6-Trp53*R193P)3Ljf/0 		Not Specified MGI:5443878


Genotype
MGI:5443876
hm1
Allelic
Composition		 Tcaptm1Rnk/Tcaptm1Rnk
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcaptm1Rnk mutation (0 available); any Tcap mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:188832 )
N
• under normal conditions, mice exhibit no abnormal cardiac phenotype
cardiac hypertrophy ( J:188832 )
• increased after transverse aortic constriction
cardiac fibrosis ( J:188832 )
• increased after transverse aortic constriction
increased response of heart to induced stress ( J:188832 )
• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice
congestive heart failure ( J:188832 )
• severe after transverse aortic constriction

cellular
increased cardiomyocyte apoptosis ( J:188832 )
• after transverse aortic constriction

homeostasis/metabolism
increased response of heart to induced stress ( J:188832 )
• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice

muscle
increased cardiomyocyte apoptosis ( J:188832 )
• after transverse aortic constriction
abnormal sarcomere morphology ( J:188832 )
• after removal of actin from cardiac sarcomeres, titin N-terminal anchorage is compromised
• however, Z-disks are normal

growth/size/body
cardiac hypertrophy ( J:188832 )
• increased after transverse aortic constriction




Genotype
MGI:5443878
cx2
Allelic
Composition		 Tcaptm1Rnk/Tcaptm1Rnk
Tg(Myh6-Trp53*R193P)3Ljf/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcaptm1Rnk mutation (0 available); any Tcap mutation (9 available)
Tg(Myh6-Trp53*R193P)3Ljf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:188832 )
N
• under normal conditions or following transverse aortic constriction, mice exhibit no abnormal cardiac phenotype and a rescue of the increased cardiomyocyte apoptosis observed in Tcaptm1Rnk homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory