Phenotypes associated with this allele

• Allele Symbol: Hcn3^tm1.1Biel
• Allele Name: targeted mutation 1.1, Martin Biel
• Allele ID: MGI:5443894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn3^tm1.1Biel/Hcn3^tm1.1Biel	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:5443912

Genotype
MGI:5443912

hm1

• Allelic Composition: Hcn3^tm1.1Biel/Hcn3^tm1.1Biel
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

prolonged QT interval ( J:188823 )

• slightly at lower heart rates

• however, QT interval is normal at high heart rates

abnormal T wave ( J:188823 )

• at lower heart rates, the Tpeak-Tend interval is slightly prolonged and T-wave amplitude is increased compared with wild-type mice

• however, T waves were normal at high heart rates

abnormal myocardial fiber physiology ( J:188823 )

• during late polarization, epicardial myocyte action potentials are shorter than in wild-type cells

• resting membrane potential is slightly shifted to a more hyperpolarized potential compared with wild-type cells

• epicardial myocytes exhibit reduced total Ih compared with wild-type cells

• however, early repolarization is normal

nervous system

abnormal action potential ( J:188823 )

• during late polarization, epicardial myocyte action potentials are shorter than in wild-type mice

• however, early repolarization is normal