Phenotypes associated with this allele

• Allele Symbol: Grn^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5443906
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grn^tm1.1Geno/Grn^tm1.1Geno	involves: 129 * C57BL/6J	MGI:5443909

Genotype
MGI:5443909

hm1

• Allelic Composition: Grn^tm1.1Geno/Grn^tm1.1Geno
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:188420 )

• show increased mortality beginning at 10 months of age

• at 23.5 months of age the probability for dying is 17.5-fold higher for mutants compared to controls

cellular

increased hepatocyte karyomegaly ( J:188420 )

• at 22 months of age

nervous system

microgliosis ( J:188420 )

• detected at 6, 12 and 21 months of age

abnormal brain morphology ( J:188420 )

• show a progressive brain ubiquitin pathology as diffuse and granular cytoplasmic neuronal staining in the cortex, CA hippocampus, subiculum, dentate gyrus, thalamus and other subcortical regions

• a 2-fold increase in autofluorescent lipofuscin pigment accumulation in many brain regions

astrocytosis ( J:188420 )

• in deeper cortical layers, hippocampus, and several subcortical regions

• increases with age

abnormal nervous system physiology ( J:188420 )

• results indicate increased cellular aging

liver/biliary system

abnormal liver morphology ( J:188420 )

• prominent aggregates of round-to-polygonal foamy histiocytes are seen at 22 months of age within sinusoids in the absence of acid fast bacilli or other inflammatory features

abnormal liver parenchyma morphology ( J:188420 )

• at 22 months of age, disarrayed masses of hepatic plates are seen along with increased microvacuolation, lipofuscinosis, and hyalinosis

• at 22 months of age, regenerative changes are observed including karyomegaly, cytomegaly, and polyploidy of hepatocytes

abnormal hepatocyte morphology ( J:188420 )

• polyploidy is seen at 22 months of age

increased hepatocyte karyomegaly ( J:188420 )

• at 22 months of age

abnormal hepatocyte physiology ( J:188420 )

• results indicate increased cellular aging in hepatocytes

behavior/neurological

abnormal spatial learning ( J:188420 )

• decrease in the efficiency in finding the invisible platform during acquisition trials

decreased grooming behavior ( J:188420 )

• slightly decreased at 15 months of age

hematopoietic system

microgliosis ( J:188420 )

• detected at 6, 12 and 21 months of age

immune system

microgliosis ( J:188420 )

• detected at 6, 12 and 21 months of age