Phenotypes associated with this allele

• Allele Symbol: Cd109^tm1Mat
• Allele Name: targeted mutation 1, Masahide Takahashi
• Allele ID: MGI:5443927
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd109^tm1Mat/Cd109^tm1Mat	B6.129S6-Cd109^tm1Mat	MGI:5443930
hm2	Cd109^tm1Mat/Cd109^tm1Mat	involves: 129S6/SvEvTac * C57BL/6J	MGI:5443929

Genotype
MGI:5443930

hm1

• Allelic Composition: Cd109^tm1Mat/Cd109^tm1Mat
• Genetic Background: B6.129S6-Cd109^tm1Mat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair growth ( J:188696 )

• phenotype is the same as in mice on a mixed 129S6/SvEvTac and C57BL/6J background

• transient

sparse hair ( J:188696 )

Genotype
MGI:5443929

hm2

• Allelic Composition: Cd109^tm1Mat/Cd109^tm1Mat
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

integument

skin inflammation ( J:188696 )

• inflammatory cell infiltration in the dermis at P21

abnormal skin adnexa morphology ( J:188696 )

sebaceous gland hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70

abnormal hair growth ( J:188696 )

• first detected at P7 and persists to P28

• hair growth is less directed

• hair growth recovers with age, with no severe impairment detected by P35

• at P14 some hairs fail to penetrate the epidermis

sparse hair ( J:188696 )

abnormal hair shaft morphology ( J:188696 )

• at P14, some hair shafts are kinky or zigzagged

abnormal hair follicle infundibulum morphology ( J:188696 )

• hyperplasia of the epidermis in the infundibular portions of the hair follicles

dilated hair follicle ( J:188696 )

• many follicles are ectatic at P21 with an accumulation of sebum

abnormal epidermal layer morphology ( J:188696 )

thick epidermis stratum basale ( J:188696 )

• apparent thickening

thick epidermis suprabasal layer ( J:188696 )

• apparent thickening

epidermal hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70

thick epidermis ( J:188696 )

• significant at most time points (except P35 and P42) after P7

• thickening is seen both in skin regions with and without hair

immune system

skin inflammation ( J:188696 )

• inflammatory cell infiltration in the dermis at P21

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:188696 )

• apparent at P7 and sustained until P70