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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stxbp2tm1Bdic
targeted mutation 1, Burton F Dickey
MGI:5443995
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stxbp2tm1Bdic/Stxbp2tm1Bdic involves: 129S * C57BL/6 MGI:5443998
ht2
 		Stxbp2tm1Bdic/Stxbp2+ involves: 129S * C57BL/6 MGI:5443999


Genotype
MGI:5443998
hm1
Allelic
Composition		 Stxbp2tm1Bdic/Stxbp2tm1Bdic
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp2tm1Bdic mutation (0 available); any Stxbp2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:188931 )
• heterozygous fail to generate homozygous mice




Genotype
MGI:5443999
ht2
Allelic
Composition		 Stxbp2tm1Bdic/Stxbp2+
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp2tm1Bdic mutation (0 available); any Stxbp2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mast cell degranulation ( J:188931 )
• decreased histamine release from stimulated peritoneal mast cells
decreased susceptibility to type I hypersensitivity reaction ( J:188931 )
• in a model of passive cutaneous anaphylaxis with decreased histamine production

respiratory system
abnormal respiratory system physiology ( J:188931 )
• mice sensitized and challenged with ovalbumin then re-stimulated with ATP aerosol exhibit reduced intracellular mucin secretion compared with wild-type mice

hematopoietic system
decreased mast cell degranulation ( J:188931 )
• decreased histamine release from stimulated peritoneal mast cells

cellular
decreased mast cell degranulation ( J:188931 )
• decreased histamine release from stimulated peritoneal mast cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory