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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nostrintm1Oess
targeted mutation 1, Stefanie Oess
MGI:5444008
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nostrintm1Oess/Nostrintm1Oess
Tg(Tek-cre)12Flv/0 		involves: 129S2/SvPas * C3H * C57BL/6 MGI:5444445


Genotype
MGI:5444445
cn1
Allelic
Composition		 Nostrintm1Oess/Nostrintm1Oess
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nostrintm1Oess mutation (0 available); any Nostrin mutation (37 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell migration ( J:188414 )
• vascular endothelial cells in the retina exhibit reduced migration with reduced number of filopodia at the leading edge of the expanding vascular plexus compared to in wild-type mice
decreased vascular endothelial cell proliferation ( J:188414 )
• vascular endothelial cells in the retina exhibit reduced proliferation

cellular
abnormal vascular endothelial cell migration ( J:188414 )
• vascular endothelial cells in the retina exhibit reduced migration with reduced number of filopodia at the leading edge of the expanding vascular plexus compared to in wild-type mice
decreased vascular endothelial cell proliferation ( J:188414 )
• vascular endothelial cells in the retina exhibit reduced proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory