Phenotypes associated with this allele

• Allele Symbol: Nostrin^tm1.1Oess
• Allele Name: targeted mutation 1.1, Stefanie Oess
• Allele ID: MGI:5444009
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nostrin^tm1.1Oess/Nostrin^tm1.1Oess	B6.129S2(Cg)-Nostrin^tm1.1Oess	MGI:5444020

Genotype
MGI:5444020

hm1

• Allelic Composition: Nostrin^tm1.1Oess/Nostrin^tm1.1Oess
• Genetic Background: B6.129S2(Cg)-Nostrin^tm1.1Oess

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:188414 )

• at P2, P5 and P7, mean vascular radius and vascularized area of the retina are reduced compared with wild-type mice

• at P5, the number of branch points at the vascular front and central region is decreased compared with wild-type mice

abnormal induced retina neovascularization ( J:188414 )

• FGF2-induced neovascularization in matrigel plug implants exhibit impaired angiogenic response compared with wild-type mice

cardiovascular system

abnormal retina vasculature morphology ( J:188414 )

• at P2, P5 and P7, mean vascular radius and vascularized area of the retina are reduced compared with wild-type mice

• at P5, the number of branch points at the vascular front and central region is decreased compared with wild-type mice

abnormal induced retina neovascularization ( J:188414 )

• FGF2-induced neovascularization in matrigel plug implants exhibit impaired angiogenic response compared with wild-type mice

decreased angiogenesis ( J:188414 )

• impaired postnatal retinal angiogenesis

abnormal vascular endothelial cell migration ( J:188414 )

• vascular endothelial cells in the retina exhibit migration with reduced number of filopodia at the leading edge of the expanding vascular plexus compared to in wild-type mice

decreased vascular endothelial cell proliferation ( J:188414 )

• vascular endothelial cells in the retina exhibit reduced proliferation

cellular

abnormal vascular endothelial cell migration ( J:188414 )

• vascular endothelial cells in the retina exhibit migration with reduced number of filopodia at the leading edge of the expanding vascular plexus compared to in wild-type mice

decreased vascular endothelial cell proliferation ( J:188414 )

• vascular endothelial cells in the retina exhibit reduced proliferation