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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gucy1b2tm2Mom
targeted mutation 2, Peter Mombaerts
MGI:5444154
Summary 2 genotypes


Genotype
MGI:5804201
hm1
Allelic
Composition		 Gucy1b2tm2Mom/Gucy1b2tm2Mom
Genetic
Background		 129S6.129P2(B6)-Gucy1b2tm2Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b2tm2Mom mutation (2 available); any Gucy1b2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:235858 )
N
• homozygotes have a normal hyperventilation response to a 10% oxygen environment indicative of normal carotid body responses, despite the failure of type B olfactory sensory neurons to respond to hypoxia




Genotype
MGI:5804173
cx2
Allelic
Composition		 Gucy1b2tm2Mom/Gucy1b2tm2Mom
Trpc2tm2Mom/Trpc2tm2Mom
Genetic
Background		 B6;129P2-Trpc2tm2Mom Gucy1b2tm2Mom/Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy1b2tm2Mom mutation (2 available); any Gucy1b2 mutation (33 available)
Trpc2tm2Mom mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory sensory neuron physiology ( J:235858 )
• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl

behavior/neurological
behavior/neurological phenotype ( J:235858 )
N
• despite the failures of type B olfactory sensory neurons, homozygotes perform normally in a Morris water maze assay for place learning, spatial memory, and spatial navigation
abnormal sensory capabilities/reflexes/nociception ( J:235858 )
• in a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen

homeostasis/metabolism
abnormal homeostasis ( J:235858 )
• fail to avoid low oxygen areas due to the failure of type B olfactory sensory neurons to detect decreased oxygen
abnormal physiological response to hypoxia ( J:235858 , J:307157 )
• Type B olfactory sensory neurons have normal calcium flux responses to NaHS, 8-bromo-cGMP and KCl but lack the correct response to reduced oxygen levels (J:307157)

nervous system
abnormal olfactory sensory neuron physiology ( J:235858 )
• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl

respiratory system
abnormal olfactory sensory neuron physiology ( J:235858 )
• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory