Phenotypes associated with this allele

• Allele Symbol: Gucy1b2^tm3Mom
• Allele Name: targeted mutation 3, Peter Mombaerts
• Allele ID: MGI:5444155
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Omp^tm4(cre)Mom/Omp^+ Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky	involves: 129P2/OlaHsd * C57BL/6J	MGI:6725130
cx2	Gucy1b2^tm3Mom/Gucy1b2^tm3Mom Trpc2^tm1Mom/Trpc2^tm1Mom	involves: 129P2/OlaHsd * C57BL/6J	MGI:5804187
cx3	Gucy1b2^tm3Mom/Gucy1b2^tm3Mom Hmox2^tm1Poss/Hmox2^tm1Poss	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J * FVB/N	MGI:6725099

Genotype
MGI:6725130

cn1

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with IFT88 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior or the increased stress-induced self-grooming that occurs that occurs in controls, but respond with normal avoidance and increased self-grooming to hypoxia

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS

Genotype
MGI:5804187

cx2

• Allelic Composition: Gucy1b2^tm3Mom/Gucy1b2^tm3Mom; Trpc2^tm1Mom/Trpc2^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:235858 , J:307157 )

• type B olfactory sensory neurons fail to respond to reduced oxygen although they respond normally to 8-bromo-cGMP and KCl (J:235858)

• type B olfactory sensory neurons respond to NaHS but fail to respond to reduced oxygen (J:307157)

taste/olfaction

abnormal olfactory sensory neuron physiology ( J:235858 )

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:235858 )

• n a conditioned place aversion test to an area of low oxygen these homozygotes fail to display a preference away from the low oxygen area consistent with the failure of type B olfactory sensory neurons to respond to low oxygen

nervous system

nervous system phenotype ( J:235858 )

N • homozygotes have a normal hyperventilation response to a 10% oxygen environment

abnormal olfactory sensory neuron physiology ( J:235858 )

respiratory system

abnormal olfactory sensory neuron physiology ( J:235858 )

Genotype
MGI:6725099

cx3

• Allelic Composition: Gucy1b2^tm3Mom/Gucy1b2^tm3Mom; Hmox2^tm1Poss/Hmox2^tm1Poss
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J * FVB/N

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to NaHS but not reduced oxygen with HMOX2 absent from type B olfactory sensory neurons, homozygotes fail to respond to hypoxia by the usual avoidance behavior and increased stress-induced self-grooming that occurs in controls, but respond with normal avoidance and increased self-grooming in response to NaHS